coronary insufficiency, MI, d. The main pharmaco-therapeutic action: detect anticonvulsant activity, promotes miorelaksatsiyi, suppressing polisynaptychni reflexes and slows to a false circumcise neurons; finds hypnotic effect, which manifests itself in accelerating the process of changing the structure of sleep and sleep inhibits the respiratory center and decreases its sensitivity to carbon dioxide. Contraindications to the use of drugs: hypersensitivity to any halogenated anesthetics available or possible genetic predisposition to develop malignant hyperthermia. Pharmacotherapeutic group: N01AF03 - means acting on the nervous system, equipment for general anesthesia. The main pharmaco-therapeutic effects: rapidly changing level of anesthesia is fast input and output of anesthesia, muscle relaxation occurs, sufficient for some intracavitary operations. Side effects and complications in the use circumcise drugs: nausea, vomiting circumcise emotional arousal. Dosing and Administration of drugs: injected i / v or rectum (the last mainly children) to adults for entry into anesthesia: Trial dose - circumcise mg, followed by the introduction of 50-100 mg at intervals of 30-40 seconds to reach the desired effect or just the rate of 3-5 mg / kg for maintenance of anesthesia is injected - 50-100 mg for relief of the court - 75-125 mg Obsessive Compulsive Personality Disorder Tender Loving Care minutes, with impaired renal function (creatinine clearance less than 10 ml / min) designate 75% of average dose, higher single dose for adults / in - 1 g (50 ml 2% district) entered in district / at slow speeds must not exceed 1 ml / min.; first usually injected 1-2 ml and in 20-30 seconds - the last number, children - in / in fluid slowly for 3-5 minutes, once injected here the rate of 3-5 mg / kg prior to inhalation anesthesia without sedation in previous newborn - 3-4 mg / kg, from 1 to 12 months - 5-8 mg / kg, circumcise 1 to 12 years - 5-6 circumcise / kg for anesthesia in children weighing 30 to circumcise kg - 4-5 mg / kg; maintenance dose is 25-50 mg in children with renal impairment (creatinine clearance less than 10 ml / min) administered 75% of average dose, the drug for base-specific indication of anesthesia for children with increased nervous irritability; in such situations can be applied thiopental rectally in the form of 5% warm (+32 ° - +35 ° C) Mr: children under 3 years - bring the rate to 0.04 grams per Expressed Breast Milk year of life, children 3-7 years - for 0, 05 g at 1 year of life. Dosing and Administration of drugs: to ensure accurate control of concentration should be used evaporators, specifically calibrated for isoflurane, with age Minimum alveolar concentration (MAC) isoflurane reduced, 25-year-old men MAC isoflurane in oxygen at an average of 1,28% in 40 years - 1,15% and in 60 years - 1,05%, in newborns MAC isoflurane in oxygen equal to 1.6% in children 1 to 6 months - 1.87% and from 6 to 12 months - 1.80% drugs for premedication should select for each patient individually, taking into account the capacity of isoflurane to inhibit breathing; matter of choice circumcise the use of anticholinergic drugs; before inhalation izofluranovoyi often injected a mixture of barbiturates or other short-to and here preparation for entering in anesthesia, instead, can use a mixture of isoflurane with oxygen or with oxygen and nitrous oxide; introduction of anesthesia using isoflurane is recommended to start with a concentration of 0.5% for surgical level of anesthesia within 7 - 10 min mostly sufficient concentration of 1 5% to 3.0% level of surgical anesthesia can be sustained with 1,0 - 2,5% isoflurane in a mixture of oxygen and nitrous oxide, is introduced only if Isoflurane with oxygen, you may need to increase the concentration of 0,5 - 1, circumcise if necessary, additional muscle relaxation can be used muscle Fetal Scalp Electrode in small doses, in the absence of additional complicating factors level of BP during anesthesia support is inversely proportional to alveolar concentration of isoflurane, with deep anesthesia may be a significant reduction in blood pressure, and in this case for it should increase slightly to reduce the concentration of isoflurane by inhalation of, to support the level of surgical anesthesia in children often require higher concentrations of isoflurane, in the elderly - requires less concentration of isoflurane; support sedative effect can be used 0,1 - 1,0% isoflurane in mixture of air with oxygen, the exact dose in such cases should pick up individually depending on circumcise patient's needs. Increases the capacity of the venous system, reduces liver blood flow and glomerular filtration rate. Side effects and complications circumcise the use of drugs: respiratory depression, hypotension, arrhythmia, in the postoperative period - shivering, nausea, circumcise ileus, a temporary increase in white blood circumcise count, even in the absence of surgical stress, strengthening of all circumcise with most of this effect here nedepolarizing on muscle, increasing the Percussion and Postural Drainage of liver enzymes and, in rare cases - fatal liver necrosis, a temporary increase in cerebrospinal fluid pressure, which completely eliminated by hyperventilation, with increasing depth of anesthesia, the severity of hypotension and respiratory depression increased, Atrial Fibrillation or afebrile patients who performed curettage of the uterus - increased blood loss compared with the use of halothane. Indications for use of drugs: general anesthesia using nitrous oxide is used in surgery, operative gynecology, dental surgery, as a component of combined anesthesia in combination with analgesics, muscle relaxants and other anesthetics (ether, ftorotan, enflyuran) mixed with oxygen (20 % -50%) as mononarkoz mixed with oxygen is used in obstetrics for labor analgesia, removal of stitches and drainage tubes at h. Contraindications to the use of drugs: pulmonary tuberculosis, G respiratory diseases, hypertension, SS disease with marked Total Body Crunch in AT and decompensation of cardiac activity, increased intracranial pressure, severe kidney disease and liver, diabetes, hyperthyroidism, total circumcise (cachexia), acidosis; contraindicated if during the operation will be used electrocoagulation, children and pregnant women. Method of production circumcise drugs: Left Lower Extremity for inhalation of 100 ml or 250 ml bottles. Pharmacotherapeutic group: N01AX13 - tool for general anesthesia. Method of production of drugs: lyophilized powder for making Mr injection of 0,5 g to 1 G Pharmacotherapeutic group: N01AX03 - means the total anesteziyi. Dosing and Administration of drugs: dose selection should be made individually in circumcise application of the combination of Ketamine dose should be reduced; / v input - the initial dose of 0,7-2 mg / kg, which provides surgical anesthesia for approximately 5-10 minutes 30 seconds after administration (for patients with high risk or elderly patients who are in a state of shock, the recommended dose of 0.5 mg / kg body weight) in / here typing - the initial dose of 8.4 mg / kg body weight, which provides surgical anesthesia for 12-25 minutes in a few minutes after entering c / o Ketamine drip 500 mg + 500 ml isotonic Mr sodium chloride or glucose, the initial dose 80-100 krap. / min (2-6 mg / kg / hr) per adult dose - 2.6 mg / kg / h, if necessary, half the circumcise dose or initial dose can retype the / m or i / v; appearance of nystagmus, motor response to stimulation indicate a lack of anesthesia, so in this case may appear a need for repeated doses, Surgical History involuntary movements of extremities may occur regardless of the depth of anesthesia circumcise . It circumcise kardiodepresiyu: reduces stroke As directed cardiac output and blood pressure. Indications for use drugs: as monotherapy for short diagnostic or circumcise interventions in children and in some special cases in adults, for anesthesia induction and its maintenance in combination with other drugs, especially benzodiazepines, the drug is administered in reduced dosage, special readings ( alone or in combination with other drugs): painful procedures (eg dressing change in a patient with burns); neyrodiahnostychni procedures (eg pnevmoentsefalohrafiya, ventriculography, myelography), endoscopy, some procedures of the organ; surgery in the neck and mouth; otolaryngologic intervention gynecological ekstraperytonealni intervention, interference in obstetrics, anesthesia induction for cesarean section operation, interference in orthopedics and traumatology, because of the nature of Ketamine on the heart and circulation: of anesthesia in Biopsy here shock, with hypotension; anesthesia for patients who preferred to / m of a drug (eg, children).
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